Online Coconut Oil

Fast-food shrinks your brain

Eating fast food — the epitome of highly processed “fake” foods — can have lasting ramifications on your brain health,…

Dr. Stephanie Seneff of MIT on Cholesterol, ApoE4, Statins, Beta Amyloid and Alzheimer’s

Here is a link to a very thorough and highly researched article by Dr. Stephanie Seneff of MIT discussing the importance of fat and cholesterol, how they work in the brain, why statin use may be counterproductive for people at risk for and dealing with Alzheimer’s, the function of beta amyloid and why a high fat diet may be beneficial.  I found this especially enlightening in its explanation of how cholesterol is packaged as it is transported throughout the body, and what it is packaged with in LDL particles, for example, may be a surprise.

http://coconutoil.com/the-clue-to-why-low-fat-diet-and-statins-may-cause-alzheimers/

Dr. Seneff has written many other similar articles of great interest to those concerned with cholesterol, statins, Alzheimer’s, autism and other neurodegenerative diseases, many of which can be downloaded from her homepage.  http://people.csail.mit.edu/seneff/

Doctors Exposing Cholesterol Myth Accused of Murder in British Press for Questioning Statin Drugs

aseem-malhotra-big-food-big-pharma

Cardiologist Dr. Aseem Malhotra spoke to the European Parliament last year (2018) exposing corruption in Big Food and Big Pharma. He promotes a dietary approach high in fat and low in carbs as a healthy, non-drug approach to combat diabetes and heart disease. View video here.

by Paul Fassa
Health Impact News

There’s a media war going on in the UK involving the issue of cholesterol-lowering statin drugs.

The British Daily Mail’s health editor, Barney Calman, labeled two medical doctors and a PhD nutritionist as “statin deniers” for their efforts in educating the public and debunking the cholesterol-heart disease causation dogma while exposing statin drug dangers. 

The two doctors are Dr. Malcolm Kendrick and Dr. Aseem Malhotra. The nutritionist is Zoe Harcombe, PhD. 

The Daily Mail article is blaming their “propaganda” as convincing people to stop taking cholesterol-lowering drugs which they claim are leading more people to suffer heart attacks as a result.

Since this is another example of corporate-sponsored “mainstream” media presenting only the pharmaceutical position on their own products and seeking to censor anyone who opposes them, we are publishing the responses from those accused of murder for exposing the dangers of statin drugs, as well as questioning the “science” used for the most widely prescribed class of drugs in the world.

Dr. Kendrick’s Response

cholesterol-hypothesis-wrong-malcolm-kendrick

Dr. Kendrick describes himself as a “Scottish doctor, author, speaker, sceptic” on his blog.

His published books include The Great Cholesterol Con and A Statin Nation: Damaging Millions in a Brave Post-health World among others.

The latter tome extends beyond statins to include many of the drugs prescribed as solutions to health issues that worsen the more they’re prescribed. 

Calman emailed Dr. Kendrick with a warning that his piece was going to be published in The Sunday Mail. It was filled with the usual promotion of statin drugs’ success at saving lives and proven safe after countless trials, confirmed as true by current mainstream medical authorities.

Dr. Kendrick argues the content of the hit piece statement by statement on his own blog.

Here’s an example of one where Calman challenges Dr. Kendrick’s use of the word “con” to describe the cholesterol-statin dogma of heart disease.

To which Kendrick replied:

Yes, I believe that people are being conned, and I believe the public are being deliberately misled. That is why I called my first book The Great Cholesterol Con.

I would point out that there has been one major placebo controlled double-blind statin study done. ALLHAT-LLT, which was funded by the National Institutes of Health in the US. The conclusions of the study, published in 2002, were that:

Pravastatin [a statin drug] did not reduce either all-cause mortality or CHD significantly when compared with usual care in older participants with well-controlled hypertension and moderately elevated LDL-C.  https://www.ncbi.nlm.nih.gov/pubmed/12479764

All of the industry-funded studies were positive. This is either a remarkable coincidence – or something else. A con perhaps?

In other words, something’s wrong with all those positive industry-funded studies when an independent government agency funded study decisively provides a contradictory result.

Calman made this accusation against Dr. Kendrick in his email to him:

Your stance on statins and the link between cholesterol and heart disease amounts to misinformation.

Dr. Kendrick replied:

Perhaps you would like to read this paper (which I co-authored) ‘LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature.’ https://www.tandfonline.com/doi/pdf/10.1080/17512433.2018.1519391?needAccess=true Which was THE most downloaded paper published by Taylor and Francis in the last year.

Or this paper ‘Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review.’ Published in the BMJ open in 2016

‘High LDL-C is inversely associated with mortality in most people over 60 years. This finding is inconsistent with the cholesterol hypothesis (ie, that cholesterol, particularly LDL-C, is inherently atherogenic). Since elderly people with high LDL-C live as long or longer than those with low LDL-C, our analysis provides reason to question the validity of the cholesterol hypothesis. Moreover, our study provides the rationale for a re-evaluation of guidelines recommending pharmacological reduction of LDL-C in the elderly as a component of cardiovascular disease prevention strategies.

Which was the most read paper in the journal for five months in a row.

All I see from your e-mail are ad-hominem attacks on me. I see no facts at all.  I hope that I have given you sufficient information

Calman concluded his email to Dr. Kendrick by stating his doubt that Kendrick was even a doctor.

There is no evidence you work in NHS practice, or as a GP in private practice.

Dr. Kendrick replied that this was libel and that he would take action against Calman and The Daily Mail:

First, I do work for the NHS [National Health Service] as a GP [General Practitioner], and if anyone wishes to claim that I do not – then that would be direct libel.

I am employed by two NHS trusts East Cheshire and CCICP (Central Cheshire Integrated Care Partnership).

Feel free to check with either trust, or look me up on the GMC [General Medical Council] website. But if anyone states that I am not employed in the NHS then I will most certainly sue. And I will win, so I would recommend caution on this point.

You can read Dr. Kendrick’s complete commentary on the Daily Mail matter by visiting his blog here.

Responses From Dr. Aseem Malhotra and Zoe Harcombe, PhD

Dr. Aseem Malhotra responded on a radio talk-show by first pointing out instances of shoddy journalism with the Daily Mail hit piece and letting the listening audience know he was filing to have the “defamatory” article “majorly fixed or retracted.” 

Here’s that short talk radio clip:

Just after the Sunday hit piece was published, PhD nutritionist Zoe Harcombe tweeted:

I don’t think statin pushers have any idea how unpopular these drugs are. Some peoples lives have been ruined by muscle pain/damage, cognitive impairment, gastric disorders – all the things warned about starting on page four of the patient leaflet. 

It’s obvious that statin information wars may continue at least until the old guard retires completely or passes on.

But at least statins are not being mandated yet like vaccinations are. We still have a choice despite the efforts of “statin pushers.”

Summarizing Calman’s Sunday Mail Hit Piece

The Calman editorial hit piece was published in The Sunday Mail edition on the second of March this year, 2019. Here a few key lines printed under each photo of the “deniers” in the article:

Zoe Harcomb … a prolific denier … recently blogged: “High cholesterol is not even associated with high heart disease, let alone a cause.”

Dr. Malcolm Kendrick, a GP from Cheshire [seems Kendrick’s lawsuit threat worked], warns …  “People are being conned. The way to avoid heart disease … has nothing to do with lowering cholesterol.”

Dr. Aseem Malhotra … claimed … “Side effects of these drugs have not been properly investigated. Patients are guinea pigs and they don’t even know it.”

Calman’s article goes on to assert that 8 million Brits taking statins daily to prevent early death from heart attacks, because statins reduce heart attack risks, is an “indisputable fact.” Later the article admits the saturated fat theory of heart disease causation has fallen apart.

The article also states that claiming high cholesterol is harmless is “fake news” and statin denier claims that statistics of statin adverse side effects are under-reported are groundless fear tactics that confuse statin users into quitting even before they start having rare “easily manageable side-effects.”

Then the article claims that information on statins not reducing the risk of death from heart attack is also “fake news.” Calman blames the fact that many thousands quit taking their prescribed statins is because of all this “fake news” from statin deniers.

Calman’s editorial considered the statin deniers most incendiary accusations against statin researchers and doctors involved financial connections with the pharmaceutical industry.

Many of us know the problem of industry-funded drug research is not a conspiracy theory. It is actually business as usual.

Calman’s hit piece may have inadvertently tipped some fence-sitting readers into finding more truth about heart disease, cholesterol, and statin drugs.

If you’re new to the controversy with cholesterol and statin drugs, there’s plenty of archived information you can access from the links below. 

Statin Archive Access

Cholesterol Truth and Myth Archive Access

Below are two videos that were originally aired on ABC Australia but subsequently banned, which clearly shows that not all doctors have bought into the saturated-fat-cholesterol theory of heart disease. See:

The Cholesterol Drug War: ABC Australia Bans Documentary Exposing Statin Drug Scandal

Comment on this article at HealthImpactNews.com.

The Great Cholesterol Con
The Truth About What Really Causes Heart Disease and How to Avoid It
by Dr. Malcolm Kendrick

the_great_cholesterol_con

Free Shipping Available!
More Info

Study: Dietary Coconut Oil Leads to Healthy Skin – Reduces Skin Infection and Inflammation

Spa model girl holding coconut and smiling.

by Brian Shilhavy
Editor, Health Impact News

A new study out of Japan and published in the European Journal of Allergy and Clinical Immunology shows how switching the dietary oil of chow fed to mice from soybean oil to coconut oil reduced skin inflammation.

The skin healing properties of coconut oil, especially virgin coconut oil, applied topically to the skin have been known for a long time.

When we first started importing virgin coconut oil from the Philippines to the U.S. market in 2001, and had started an online discussion group, some of the most powerful testimonies we started receiving from people were how they were using virgin coconut oil for their skin conditions.

Even though coconut oil is sold as a dietary oil, people started applying it topically and seeing tremendous results for their skin conditions such as acne, eczema, keratosis polaris, psoriasis, rosacea, and fungal infections. Read some of these incredible testimonies here:

Virgin Coconut Oil for Skin Health

We have suspected for years that the reason people in tropical climates who eat their traditional diets which are high in the saturated fats of coconut oil had such beautiful skin, even though they are exposed to the sun to a greater degree than westerners, is because of the high amounts of coconut oil in their diet, which does not oxidize and cause free radical damage as polyunsaturated fats do.

Skin cancer, for example, is almost unheard of in tropical climates like the Philippines, but common in western nations, even in colder climates with far less exposure to the sun.

Researchers in Japan apparently wanted to test this theory of dietary coconut oil reducing allergic skin inflammation in the laboratory:

Coconut oil is used as a dietary oil worldwide, and its healthy effects are recognized by the fact that coconut oil is easy to digest, helps in weight management, increases healthy cholesterol and provides instant energy.

Although topical application of coconut oil is known to reduce skin infection and inflammation, whether dietary coconut oil has any role in decreasing skin inflammation is unknown.

In this study, we showed the impact of dietary coconut oil in allergic skin inflammation by using a mouse model of contact hypersensitivity (CHS).

So they replaced the soybean oil commonly used in mice chow with coconut oil.

Soybean oil has been the most common dietary oil in the western diet since World War II, when expeller-pressed seed technology allowed manufactures to extract oil from the soybean, one of the main cash crops in the U.S. and heavily subsidized to dominate the world market in dietary oils.

Soybean oil is high in Omega 6 fatty acids, and it is commonly known that most westerners have an unhealthy balance of Omega 3 to Omega 6 fatty acids leading to various health problems, as most westerners need more Omega 3 fatty acids and far less Omega 6 fatty acids in their diet.

This point was noted by the researchers:

A high n-6/n-3 FA ratio is linked to many chronic inflammatory diseases, including cardiovascular disease, obesity, non-alcoholic fatty liver disease, and inflammatory bowel disease.

Coconut oil does not contain appreciable amounts of either of these classes (Omega 3 or Omega 6) of essential fatty acids.

Previous studies using dietary coconut oil have shown its health benefits toward hepatotoxicity, together with altered lipid profiles in the body.

Another unique feature of coconut oil is the low abundance of both n-3 and n-6 essential FAs.

Omega 3 fatty acids are linked to anti-inflammatory effects, and since coconut oil does not contain any appreciable amount of Omega 3s, they could not be attributed to lower allergic inflammation in the skin with the mice fed the coconut oil diet.

After 2 months of comparing the mice on the standard soybean oil chow and the ones with coconut oil, they found that there was:

Amelioration of skin allergic inflammation in mice maintained on dietary coconut oil.

Numerous studies have suggested the beneficial effects of coconut in the treatment of diabetes, obesity, cardiovascular diseases, and Alzheimer’s disease, through components including dietary fiber, vitamins, minerals, and phenolic compounds.

Here, we show that FAs derived from coconut oil play important roles in the maintenance of health by controlling allergic inflammation in mice; this is consistent with previous reports that topical and dietary coconut oil is beneficial for the prevention and amelioration of dermatitis.

Since there are no essential fatty acids in coconut oil, what did the researchers attribute in the coconut oil as beneficial in reducing allergic skin inflammation?

In terms of FA composition, one of the unique characteristics of coconut oil is the large amount of MCFAs (medium chain fatty acids); these are easy to digest and could potentially contribute to prevention of obesity and diabetes and have demonstrated protective effects against intestinal inflammation and colitis.

Of the medium chain fatty acids found in coconut oil, the most predominate one is lauric acid. Coconut oil is nature’s richest source of lauric acid, making up about 50% of coconut oil, with human breast milk being a distant second.

Apart from the low contents of n-3 and n-6 FAs, coconut oils uniquely are abundantly composed of lauric acid (Figure 2A). Consistently, lauric acid concentration was higher in coconut mice than in soybean mice (Figure 2C), prompting us to examine the probable roles of lauric acid in CHS.

The other component the researchers looked at was mead acid.

Mead acid, a metabolite of oleic acid, has known anti-inflammatory properties. Because mice maintained on coconut oil show EFAD (essential fatty acid deficiency) and body accumulation of mead acid, we compared the abundances of mead acid in the serum of coconut and soybean mice. Mead acid levels were substantially higher in coconut mice.

With the USDA and FDA currently condemning coconut oil as unhealthy due to its high saturated fat content, it is certainly no surprise that allergic skin inflammation diseases are becoming so common in the United States.

If you want healthier skin, cut down on polyunsaturated vegetable oils and switch to coconut oil as a more significant portion of your diet.

Reference

“Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice” – European Journal of Allergy and Clinical Immunology – 06 March 2019 – Prabha Tiwari, Takahiro Nagatake, So‐ichiro Hirata, Kento Sawane, Azusa Saika, Yuki Shibata, Sakiko Morimoto, Tetsuya Honda, Jun Adachi, Yuichi Abe, Junko Isoyama, Takeshi Tomonaga, Hiroshi Kiyono, Kenji Kabashima, Jun Kunisawa. Abstract.

About the author: Unlike many people who write about coconut oil by simply reading about it, Brian Shilhavy actually lived in a coconut producing area of the Philippines for several years with his family, observing firsthand the differences between the diet and health of the younger generation and those of his wife’s parents’ generation still consuming a traditional diet. This led to years of studying Philippine nutrition and dietary patterns first hand while living in a rural farming community in the Philippines. Brian is the author of the best-selling book: Virgin Coconut Oil: How it has changed people’s lives and how it can change yours!

Includes 85 recipes – Free shipping available!

Read the Virgin Coconut Oil eBook on Your Mobile Device!

 

 

choosing-the-best-coconut-oil

Dianne’s Healthy Coconut Almond Macaroons

I’ve posted this recipe before, but it’s worth posting again. This is one of my favorite low carb, gluten free cookie recipes. Imagine, you can snack on something good for you that actually helps you lose weight!

Ingredients:

1 1/2 cups unsweetened dried coconut
1/2 cup almond meal (finely ground almonds)
2 t. coconut flour
4 T. warm water
4 T. raw honey
2 eggs, beaten
1 t. vanilla
1/4 t. sea salt

Directions:

Preheat the oven to 400 degrees. Grease a cookie sheet with coconut oil.

Stir the warm water and honey together. Add the vanilla, eggs, salt, almond meal, coconut flour and coconut. Mix well. If the mixture is runny, let it sit for a few minutes so the coconut can rehydrate. If it is still runny, add another teaspoon of coconut flour. Drop by rounded tablespoons full onto the cookie sheet, about 1 inch apart. Bake for 12 – 15 minutes. The outside of the cookie should be golden brown, while the inside is soft.

Makes about 24 cookies.

If you don’t like the taste of almonds or you want your macaroons whiter, just substitute another 1/2 cup dried coconut for the almond meal.

If you want to get decadent, dip the bottoms of the finished macaroons into melted extra dark chocolate chips mixed with a little coconut oil. Refrigerate.

• • • • •

Learn the secrets thousands are using to lose weight and get healthier with coconut oil diets. Visit our site at http://coconut-oil-diet.com and start losing weight today!

Dispelling the Myth that LDL Cholesterol is “Bad”

Structure of Low-density lipoprotein (LDL): apolipoprotein (apo B-100)

by Paul Fassa
Health Impact News

Independently-sourced research challenges the idea that LDL (low-density lipoprotein) is the “bad cholesterol,” and causes heart disease.

However, the theory that LDL is “bad” persists in the mainstream media and with Big Pharma, mainly because they would lose billions of dollars in drugs and treatments to admit the theory lacks merit.

The hypothesis of saturated fat creating artery-clogging cholesterol as the source of heart disease should be considered dead and incapable of resuscitating, based on the scientific evidence.

But one still sees and hears fearful statements about lowering cholesterol and avoiding heart disease, mostly on mainstream media but even all too often on internet alternative media sources. 

Current research is showing LDL is not dangerous and it’s not an accurate marker for pending heart disease. 

An Explanation of Cholesterol and How LDL and HDL are Differentiated   

Mainstream medicine and pharma-funded research maintains that LDL is the cholesterol that causes coronary congestion.

It’s the “bad cholesterol.”

Perhaps because research has discovered people with high HDL (high-density lipoprotein) live longer than those with low HDL, HDL is now considered the “good cholesterol.” 

For the most part, cholesterol is cholesterol and it’s all good for so many hormonal and structural purposes in our bodies. 

Cholesterol is a waxy lipid substance. It doesn’t mix with our watery plasma. It needs to be carried in the blood’s plasma by lipoproteins, tiny protein spheres that carry cholesterol to wherever it’s needed in the body.

Our bodies actually need cholesterol for many hormonal and cell building functions.

Cholesterol is categorized by the density of its lipoprotein carriers. The density is a factor of the ratio of protein to cholesterol in the particles. High-density lipoproteins (HDL) are smaller with around 50 percent protein and 20 percent cholesterol.

Low-density lipoproteins (LDL) are larger and contain around 25 percent protein and 50 percent cholesterol.

The mainstream claim is that HDL is the “good cholesterol” because it sweeps up the LDL cholesterol from arteries or other unwanted areas and routes it back to the liver where it came from. (Source)

But if the liver generates LDL cholesterol particles that are carried to various organ tissue areas, including the brain and nervous system as needed, why is it called “bad cholesterol?” 

The conventional explanation has been that LDL particles stick to the endothelial cells of inner arterial walls.

Before we explore the veracity of this claim, let’s have a look at how important cholesterol is for our health.

How cholesterol helps keep us at optimum health:

  • It helps to produce cell membranes, which are made of fat.
  • It is a precursor to the manufacturing of hormones, including sex hormones and cortisone.
  • It is the first step in converting the sun’s UVB rays into vitamin D. 
  • It helps to formulate bile acids for digesting fat.
  • It is needed for proper function of serotonin receptors in the brain
  • It is involved with supplying the CoQ10 coenzyme, a vital cellular energy source in muscle tissue especially the heart muscle.
  • It helps form memories in the brain.
  • It is important in maintaining the health of the intestinal wall.
  • It builds and maintains the myelin sheath – a protective fatty tissue wrapping nerve fibers, which when damaged causes MS and other neurological diseases.
  • It is vital toward building brain cells in the brain, which contains 25 percent of your body’s total cholesterol (Source)

It logically follows that by drastically lowering cholesterol with statin drugs, at least some of the listed functions will be impaired leading to some serious side effects such as muscle or tendon tearing, chronic fatigue, mind fog or impaired memory, and even heart attacks. 

Many statin users who had experienced inexplicable side effects recovered completely within a few short weeks after no longer dosing with statins. 

The LDL Theory of Heart Disease is Busted – With an Asterisk

Several independent scientists, physicians, and cardiologists have busted the LDL theory of cholesterol arterial clogging. 

The title below links to an article covering a review study by several international researchers published in September of 2018. Their peer-reviewed published paper rips the LDL theory of heart disease causation to shreds. See:

Experts Review of 107 Scientific Studies: Cholesterol Does Not Cause Heart Disease – Statin Drugs are Useless

Of course, the research is marginalized and the medical old guard attacked the researchers via mainstream media to keep the war against LDL (the bad cholesterol) going and maintain statin drug profits.

Cholesterol fear is maintained now that LDL remains as the cholesterol culprit for heart disease. The mantra to avoid saturated fat and lower cholesterol continues.

The same network of doctors and scientists, The International Network of Cholesterol Skeptics (THINCS) who put together the review above, supplied suggestions of potential causes of heart disease other than cholesterol. See:

Network of Cholesterol Skeptics Researchers: Abandon the LDL Cholesterol Theory of Heart Disease and Look at More Important Risk Factors

The suggestions in the above article are examples of where heart disease research should go now that the lipid theory of heart disease has been ripped to shreds, not only by THINCS members but others as well. 

Dr. Ronald M. Kraus, MD is a co-creator of a device that can sort out VLDL (very low-density lipoprotein), from LDL.

VLDL (very low-density lipoproteins) is the “asterisk” mentioned in the title of this section. It will be covered in the next section after this quote by Dr. Kraus:

Low-fat diets are old news, you say? Try telling that to the makers of, say, Baked Lays. It will take us years to shake off the damage done by broadly implicating fat in the diet. Everybody I know in the field — everybody — recognized that a simple low-fat message was a mistake. 

I spend a lot of time talking to reporters and trying to explain that dietary cholesterol is not the same as blood cholesterol. (Source) 

In other words, the saturated fat causation of heart disease is wrong, but it still lingers enough for the pharmaceutical and processed food industries to profit from this “cholesterol con.” 

Despite this uprising from several in the medical science community, the public perception is still held hostage to the official nutritional and medical dogmatic doctrine of using high LDL as a marker for heart disease. 

The mainstream medical monopoly’s use of mainstream media, which thrives from Big Pharma’s advertising revenue, helps keep the cholesterol con afloat. Behind the mainstream public scenes, those who know better are publicly challenged ad hominem while the details of their findings wind up in mainstream media obscurity. 

A Little on VLDL – Very Low-Density Lipoproteins

These lipoproteins contain minuscule cholesterol levels but are high in triglyceride lipids. Triglyceride lipids form the fat from unused carbohydrate energy, like sugar.

Triglycerides are intended as storage to be utilized for energy when other dietary energy sources wane or the need for more energy arises.

But that very rarely happens in our culture of accessible cheap foods, especially with processed and junk fast foods.

Add “energy drinks” to the mix, and as the body gets overwhelmed with foods that disrupt metabolic processing, the triglyceride fat just keeps accumulating. 

The smaller, heavier VLDL particles can burrow into inner arterial walls and cause inflammation with their oxidation-prone triglycerides.

Guess what tries to patch up that inflammation?

Cholesterol, manufactured and distributed by the liver, aka LDL. Internal tissue repair is one of its functions.

And what’s been discovered and is gradually being accepted everywhere, except for mainstream medicine, government nutritional agencies, and the mainstream media, is that excess sugar, refined carbohydrates, and HFCS (high fructose corn syrup) are the culprits behind obesity, diabetes 2, and coronary artery disease (CAD).

Dr. Robert Lustig, pediatric endocrinologist professor at the University of California, San Francisco, has been on a mission exposing the role sugar and HFCS play with creating heart disease by causing arterial damage with triglyceride fats carried by the VLDL particles. 

Dr. Lustig explains:

So we were using the wrong marker [cholesterol] all along. It turned out the triglyceride was way worse. Triglyceride is basically what your liver does to sugar. And again, sugar was the problem, Yudkin* was right, and the food industry killed him. [* added] (Source)

*Around the time Ancel Keys was claiming fat was the source of heart disease, a British Researcher, Professor John Yudkin, was researching sugar as the source. Yudkin’s research was trashed by the sugar industry to avoid financial loss by scapegoating fat as the source of coronary heart disease. 

The whole statin drug industry, along with the food industry and its processed low-fat foods that would accommodate the low and no fat diet philosophy are shams based on the totally erroneous assumption that cholesterol from dietary saturated fats is the main source of cardiovascular disease. 

Video: Dr. Nadir Ali, MD: The Paradox of Insulin Resistance versus LDL Cholesterol

Comment on this article at HealthImpactNews.com.

Latest Alzheimer’s Blockbuster Drug Fails to Complete Phase 3 Trials

Drugs-vs-Coconut-Oil

by Paul Fassa
Health Impact News

As has been reported numerous times here at Health Impact News for the past 6 years or so, the pharmaceutical industry has been desperate to find an Alzheimer’s drug to market to an aging baby boomer population with ever increasing numbers of Alzheimer’s Disease cases.

And yet, billions of dollars have been invested in potential drugs only to see these drugs never make it out of the trial phase and come to market, because they do not significantly help Alzheimer’s patients.

Biogen and their partner Eisai are the latest pharmaceutical companies to throw in the towel regarding their Alzheimer’s drug aducanumab, which has failed to make it out of phase 3 trials.

Many drug researchers have now abandoned the theory of amyloid plaque accumulation in the brain as the causative factor of Alzheimer’s. Could aducanumab’s failure be the last nail in the coffin for this theory, as natural approaches to Alzheimer’s such as coconut oil and the ketogenic diet see more positive results?

Biogen Endures the Latest Pharmaceutical Failure with Solving Alzheimer’s Disease

An independent risk assessment during Biogen’s early phase 3 trials signaled the end of their efforts to develop a “blockbuster drug” based on aducanumab for Alzheimer’s.

Aducanumab is a solution of synthetically-derived antibodies based on human cells that have been specifically arranged to attack amyloid beta (AB) antigens. Amyloid beta plaques are considered the stuff of Alzheimer’s disease. Bioengineering antibodies is one aspect of immunotherapy.

Phase 3 trials are near the end of clinical trials involving humans with the largest numbers, 300 to 3,000 humans with the disease the drug is intended for. Before clinical trials begin, there must be satisfactory in vitro and in vivo (lab animal) results that suggest possible medical merits.

Phase 3 trials are considered pivotal towards the final marketing license granted by the FDA upon receiving two apparently positive clinical trial reports from the pharmaceutical company. There’s a phase 4, which is the post-market gathering of adverse side effects. (Source)

Cambridge, Massachusetts-based Biogen and its partner for these trials, Tokyo, Japan-based Eisai wound up sending 3,200 early-phase Alzheimer’s patients to their international homes with a “sorry” and “thanks.

The independent risk assessment that predicted there would be no successful efficacious outcome on any significant level was convincing enough to drop the risk of losing more money and failing their stockholders. 

The expected outcome was increased memory and mental acuity of most patients with minimal severe side effects for their phase 3 participants with early-stage Alzheimer’s disease. 

If there were no adverse events or safety issues among the participants, as Biogen officially stated, then they were not getting enough restored memories, cognitive improvement, and improved dispositions to continue throwing money at the project.

If the earlier in vitro tests (lab culture experiments) had shown strong evidence of getting rid of amyloid beta plaque, why wasn’t it working to at least marginally improve enough human trial participants to continue the phase 3 trials?

University College of London’s John Hardy’s answer was:

This tells us that removal of amyloid in people with the disease is too late. Amyloid is a disease trigger. Once the neurodegenerative disease process is up and running, it is up and running. (Source)

David Holtzman, Washington University, St. Louis, added:

Even though this trial was in the early symptomatic phase of AD [Alzheimer’s disease], it is still in the phase when Aβ [amyoid beta] is no longer likely to be the driving process but where *tau and inflammation probably are. (Source)

Ron Petersen, Mayo Clinic, Rochester, Minnesota wrote regarding this recent failure to medically solve mainstream medicine’s AD riddle:

I think this solidifies the opinion that amyloid-targeted therapies do not have a clinical effect at the symptomatic stages of the disease process.

We clearly need other targets, and *tau is the leading candidate for now. (Source)

*Tau refers to the protein in brain cells that normally facilitates brain cell communication. It’s hypothesized that damaged or distorted tau proteins in brain cells may be the cause of Alzheimer’s disease that leads to the formation of amyloid beta plaque. (Source) 

These three medical academics seem to be saying it’s possible all the pharmaceutical whizzes so far have been targeting the end result of Alzheimer’s disease instead of the potential source.  

Maybe that’s why, prior to Biogen-Eisai’s failure, Eli Lilly’s AD (Alzheimer’s disease) drug failed during phase 3 trials. Other failures with developing a marketable AD drug include Johnson & Johnson, Pfizer, and Roche.

Thus far, the pharmaceutical industry has struck out each time at bat against AD. (Source)

Natural Options That Have Demonstrated Dramatic Improvements for AD Symptoms

Virgin Coconut Oil

An easier, less expensive, and more accessible alternative natural option for Alzheimer’s and other associated neurological disorders would be coconut oil.

See:

Coconut Oil Offers Hope for Alzheimer’s, Parkinson’s, and ALS

Health experts and medical practitioners not under Big Pharma’s thumb have realized that Alzheimer’s disease and other neurological disorders are symptoms of type 2 diabetes of the brain.

Insulin resistance inhibits glucose from entering into cells for energy. It is the hallmark of diabetes 2.

Because of cellular insulin resistance, glucose is not making it into brain cells to energize them. Insulin is needed to carry glucose into cells for the energy required for proper metabolism. Some are calling this insulin resistance in the brain diabetes type 3.

See:

Research Continues to Show Alzheimer’s is a Type 3 Diabetes

But medium chain fatty acids or triglycerides (MCTs) provide ketones that are energy sources not dependent on insulin to carry them into brain cells. MCTs are not stored as fatty tissue triglycerides for future energy use.

The liver processes MCTs to produce ketones that are available for immediate energy use in brain cells without the need for insulin. That’s why so many have turned to virgin coconut oil to reduce and even reverse symptoms of Alzheimer’s, Parkinson’s disease, and other neurological disorders.

See:

The Failure of the Medical System to Treat Alzheimer’s

Not only are the results without adverse side effects, coconut oil offers other health benefits.

See:

Study: Coconut Oil’s Lauric Acid Reduces High Blood Pressure

Depending on the severity of one’s neurological disorder, two to four tablespoons daily is usually sufficient for improving Alzheimer’s and Parkinson’s conditions as well as performing as a natural antibiotic, anti-fungal, and antiviral agent.

Cannabis

Using cannabis for Alzheimer’s or Parkinson’s disease and other related brain and nervous system disorders usually requires full spectrum cannabis with THC. 

It has even been laboratory tested for what it can do for Alzheimer’s disease by the Salk Institute and the University of California, both in La Jolla, California.

Their findings were published in 2016 as Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids with the following conclusion:

Cannabinoids such as tetrahydrocannabinol [THC] stimulate the removal of intraneuronal Aβ, block the inflammatory response, and are protective. Altogether these data show that there is a complex and likely autocatalytic inflammatory response within nerve cells caused by the accumulation of intracellular Aβ, and that this early form of proteotoxicity can be blocked by the activation of cannabinoid receptors. (Study text)

This means that using cannabis with THC for any reason prevents amyloid beta formations and brain cell inflammation significantly, greatly reducing the risk of Alzheimer’s or other neurodegenerative diseases by eliminating the root cause before any symptoms arise, or stated simply, nipping it in the bud.

See:

Study: Cannabis More Effective Than Pharmaceutical Drugs for Age-Related Neurodegenerative Diseases Like Alzheimer’s

Cannabis has opened up dramatically for medical use in over half of America’s states. But not all states have medical cannabis arrangements, and some of those that do may not allow full spectrum cannabis with THC for Alzheimer’s or Parkinson’s disease.

A cannabis doctor or cannabis dispensary consultant can be helpful with advising what condition other than Alzheimer’s or Parkinson’s disease a patient can use that’s allowable under his or her state’s guidelines.

This cannabis medical allowances state by state guide might be helpful.

Comment on this article at HealthImpactNews.com.

Coconut Spinach

  • 2-3 lbs. fresh organic spinach
  • 2 Tablespoons butter
  • 1/2 cup minced onion
  • 1/2 cup unsweetened coconut milk
  • 1/4 cup crushed blanched almonds, cashews or pine nuts
  • 1 teaspoon salt
  • 1/2 teaspoon seeded and crushed dried red chili pepper (optional)
  • 1 Tablespoon of unsweetened coconut, lightly toasted.

Place spinach in covered pot, with just enough water to cling to leaves. Cook just until spinach is wilted and tender. Set aside. 

Saute minced onion in butter. Stir in coconut milk, nuts, salt and chili pepper. Add to spinach. Reheat and serve in heated bowl. Top with toasted coconut.

This recipe is especially good if you are on a coconut oil diet! If you want to learn more about how to lose weight with coconut oil, check out my website at http://coconut-oil-diet.com.

Coconut Potato Pancakes (also called Coconut Fritters)

Ingredients:

  • 2 cups unsweetened coconut milk
  • 4 large baking potatoes
  • 1/2 cup unsweetened dried coconut
  • 1/2 cup flour
  • 1 teaspoon baking powder
  • 1/4 tsp. Salt
  • 3 free range eggs, beaten
  • Coconut oil
  • 1/2 cup butter, melted, for serving

Directions:

Boil the potatoes in their skins, cool slightly and peel. Mash the potatoes. Add the eggs.

Sift the flour together with the baking powder and salt. Beat this mixture
into the potato and egg mixture.

Add the coconut milk. Drop batter by large spoonfuls onto a hot heavy frying pan, well-greased with coconut oil. Turn the pancakes when golden on one side (3-4 minutes). Cook until the second side is golden brown.

Serve with the melted butter on the side. Serves 4 to 6.



This recipe is especially good if you are on a coconut oil diet! If you want to learn more about how to lose weight with coconut oil, check out my website at http://coconut-oil-diet.com