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EverythingProduct SearchIt is never ever far too late to get in shape and reduce weight,…

Continue Reading 9 Healthy Meal Recipes That Help You Lose Belly Fat

9 Healthy Meal Recipes That Help You Lose Belly Fat

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EverythingProduct SearchJump to recipe Are you transitioning to a low-carb or keto diet but don’t…

Continue Reading 4-Ingredient Keto Almond Flour Bread

4-Ingredient Keto Almond Flour Bread

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EverythingProduct SearchKale is America’’ s superfood sweetie, and it’’ s simple to see why. It’’…

Continue Reading Is eating raw kale *actually* bad for you? Here’s what the experts say

Is eating raw kale *actually* bad for you? Here’s what the experts say

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EverythingProduct SearchThere are numerous kinds of aloe plants, with Aloe Vera being the most typical….

Continue Reading Types of Aloe Plants: Different Types of Aloe (Vera) Plants

Types of Aloe Plants: Different Types of Aloe (Vera) Plants

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EverythingProduct SearchCan You Have Bread on Keto? And Should You? 20 Insanely Delicious Keto Bread…

Continue Reading The Best Keto Bread Recipes: 30 Recipes You Won’t Believe are Low-Carb

The Best Keto Bread Recipes: 30 Recipes You Won’t Believe are Low-Carb

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Here is a link to a very thorough and highly researched article by Dr. Stephanie Seneff of MIT discussing the importance of fat and cholesterol, how they work in the brain, why statin use may be counterproductive for people at risk for and dealing with Alzheimer’s, the function of beta amyloid and why a high fat diet may be beneficial.  I found this especially enlightening in its explanation of how cholesterol is packaged as it is transported throughout the body, and what it is packaged with in LDL particles, for example, may be a surprise.

http://coconutoil.com/the-clue-to-why-low-fat-diet-and-statins-may-cause-alzheimers/

Dr. Seneff has written many other similar articles of great interest to those concerned with cholesterol, statins, Alzheimer’s, autism and other neurodegenerative diseases, many of which can be downloaded from her homepage.  http://people.csail.mit.edu/seneff/

Continue Reading Dr. Stephanie Seneff of MIT on Cholesterol, ApoE4, Statins, Beta Amyloid and Alzheimer’s

Dr. Stephanie Seneff of MIT on Cholesterol, ApoE4, Statins, Beta Amyloid and Alzheimer’s

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Drugs-vs-Coconut-Oil

by Paul Fassa
Health Impact News

As has been reported numerous times here at Health Impact News for the past 6 years or so, the pharmaceutical industry has been desperate to find an Alzheimer’s drug to market to an aging baby boomer population with ever increasing numbers of Alzheimer’s Disease cases.

And yet, billions of dollars have been invested in potential drugs only to see these drugs never make it out of the trial phase and come to market, because they do not significantly help Alzheimer’s patients.

Biogen and their partner Eisai are the latest pharmaceutical companies to throw in the towel regarding their Alzheimer’s drug aducanumab, which has failed to make it out of phase 3 trials.

Many drug researchers have now abandoned the theory of amyloid plaque accumulation in the brain as the causative factor of Alzheimer’s. Could aducanumab’s failure be the last nail in the coffin for this theory, as natural approaches to Alzheimer’s such as coconut oil and the ketogenic diet see more positive results?

Biogen Endures the Latest Pharmaceutical Failure with Solving Alzheimer’s Disease

An independent risk assessment during Biogen’s early phase 3 trials signaled the end of their efforts to develop a “blockbuster drug” based on aducanumab for Alzheimer’s.

Aducanumab is a solution of synthetically-derived antibodies based on human cells that have been specifically arranged to attack amyloid beta (AB) antigens. Amyloid beta plaques are considered the stuff of Alzheimer’s disease. Bioengineering antibodies is one aspect of immunotherapy.

Phase 3 trials are near the end of clinical trials involving humans with the largest numbers, 300 to 3,000 humans with the disease the drug is intended for. Before clinical trials begin, there must be satisfactory in vitro and in vivo (lab animal) results that suggest possible medical merits.

Phase 3 trials are considered pivotal towards the final marketing license granted by the FDA upon receiving two apparently positive clinical trial reports from the pharmaceutical company. There’s a phase 4, which is the post-market gathering of adverse side effects. (Source)

Cambridge, Massachusetts-based Biogen and its partner for these trials, Tokyo, Japan-based Eisai wound up sending 3,200 early-phase Alzheimer’s patients to their international homes with a “sorry” and “thanks.

The independent risk assessment that predicted there would be no successful efficacious outcome on any significant level was convincing enough to drop the risk of losing more money and failing their stockholders. 

The expected outcome was increased memory and mental acuity of most patients with minimal severe side effects for their phase 3 participants with early-stage Alzheimer’s disease. 

If there were no adverse events or safety issues among the participants, as Biogen officially stated, then they were not getting enough restored memories, cognitive improvement, and improved dispositions to continue throwing money at the project.

If the earlier in vitro tests (lab culture experiments) had shown strong evidence of getting rid of amyloid beta plaque, why wasn’t it working to at least marginally improve enough human trial participants to continue the phase 3 trials?

University College of London’s John Hardy’s answer was:

This tells us that removal of amyloid in people with the disease is too late. Amyloid is a disease trigger. Once the neurodegenerative disease process is up and running, it is up and running. (Source)

David Holtzman, Washington University, St. Louis, added:

Even though this trial was in the early symptomatic phase of AD [Alzheimer’s disease], it is still in the phase when Aβ [amyoid beta] is no longer likely to be the driving process but where *tau and inflammation probably are. (Source)

Ron Petersen, Mayo Clinic, Rochester, Minnesota wrote regarding this recent failure to medically solve mainstream medicine’s AD riddle:

I think this solidifies the opinion that amyloid-targeted therapies do not have a clinical effect at the symptomatic stages of the disease process.

We clearly need other targets, and *tau is the leading candidate for now. (Source)

*Tau refers to the protein in brain cells that normally facilitates brain cell communication. It’s hypothesized that damaged or distorted tau proteins in brain cells may be the cause of Alzheimer’s disease that leads to the formation of amyloid beta plaque. (Source) 

These three medical academics seem to be saying it’s possible all the pharmaceutical whizzes so far have been targeting the end result of Alzheimer’s disease instead of the potential source.  

Maybe that’s why, prior to Biogen-Eisai’s failure, Eli Lilly’s AD (Alzheimer’s disease) drug failed during phase 3 trials. Other failures with developing a marketable AD drug include Johnson & Johnson, Pfizer, and Roche.

Thus far, the pharmaceutical industry has struck out each time at bat against AD. (Source)

Natural Options That Have Demonstrated Dramatic Improvements for AD Symptoms

Virgin Coconut Oil

An easier, less expensive, and more accessible alternative natural option for Alzheimer’s and other associated neurological disorders would be coconut oil.

See:

Coconut Oil Offers Hope for Alzheimer’s, Parkinson’s, and ALS

Health experts and medical practitioners not under Big Pharma’s thumb have realized that Alzheimer’s disease and other neurological disorders are symptoms of type 2 diabetes of the brain.

Insulin resistance inhibits glucose from entering into cells for energy. It is the hallmark of diabetes 2.

Because of cellular insulin resistance, glucose is not making it into brain cells to energize them. Insulin is needed to carry glucose into cells for the energy required for proper metabolism. Some are calling this insulin resistance in the brain diabetes type 3.

See:

Research Continues to Show Alzheimer’s is a Type 3 Diabetes

But medium chain fatty acids or triglycerides (MCTs) provide ketones that are energy sources not dependent on insulin to carry them into brain cells. MCTs are not stored as fatty tissue triglycerides for future energy use.

The liver processes MCTs to produce ketones that are available for immediate energy use in brain cells without the need for insulin. That’s why so many have turned to virgin coconut oil to reduce and even reverse symptoms of Alzheimer’s, Parkinson’s disease, and other neurological disorders.

See:

The Failure of the Medical System to Treat Alzheimer’s

Not only are the results without adverse side effects, coconut oil offers other health benefits.

See:

Study: Coconut Oil’s Lauric Acid Reduces High Blood Pressure

Depending on the severity of one’s neurological disorder, two to four tablespoons daily is usually sufficient for improving Alzheimer’s and Parkinson’s conditions as well as performing as a natural antibiotic, anti-fungal, and antiviral agent.

Cannabis

Using cannabis for Alzheimer’s or Parkinson’s disease and other related brain and nervous system disorders usually requires full spectrum cannabis with THC. 

It has even been laboratory tested for what it can do for Alzheimer’s disease by the Salk Institute and the University of California, both in La Jolla, California.

Their findings were published in 2016 as Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids with the following conclusion:

Cannabinoids such as tetrahydrocannabinol [THC] stimulate the removal of intraneuronal Aβ, block the inflammatory response, and are protective. Altogether these data show that there is a complex and likely autocatalytic inflammatory response within nerve cells caused by the accumulation of intracellular Aβ, and that this early form of proteotoxicity can be blocked by the activation of cannabinoid receptors. (Study text)

This means that using cannabis with THC for any reason prevents amyloid beta formations and brain cell inflammation significantly, greatly reducing the risk of Alzheimer’s or other neurodegenerative diseases by eliminating the root cause before any symptoms arise, or stated simply, nipping it in the bud.

See:

Study: Cannabis More Effective Than Pharmaceutical Drugs for Age-Related Neurodegenerative Diseases Like Alzheimer’s

Cannabis has opened up dramatically for medical use in over half of America’s states. But not all states have medical cannabis arrangements, and some of those that do may not allow full spectrum cannabis with THC for Alzheimer’s or Parkinson’s disease.

A cannabis doctor or cannabis dispensary consultant can be helpful with advising what condition other than Alzheimer’s or Parkinson’s disease a patient can use that’s allowable under his or her state’s guidelines.

This cannabis medical allowances state by state guide might be helpful.

Comment on this article at HealthImpactNews.com.

Continue Reading Latest Alzheimer’s Blockbuster Drug Fails to Complete Phase 3 Trials

Latest Alzheimer’s Blockbuster Drug Fails to Complete Phase 3 Trials

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  • 2-3 lbs. fresh organic spinach
  • 2 Tablespoons butter
  • 1/2 cup minced onion
  • 1/2 cup unsweetened coconut milk
  • 1/4 cup crushed blanched almonds, cashews or pine nuts
  • 1 teaspoon salt
  • 1/2 teaspoon seeded and crushed dried red chili pepper (optional)
  • 1 Tablespoon of unsweetened coconut, lightly toasted.

Place spinach in covered pot, with just enough water to cling to leaves. Cook just until spinach is wilted and tender. Set aside. 

Saute minced onion in butter. Stir in coconut milk, nuts, salt and chili pepper. Add to spinach. Reheat and serve in heated bowl. Top with toasted coconut.

This recipe is especially good if you are on a coconut oil diet! If you want to learn more about how to lose weight with coconut oil, check out my website at http://coconut-oil-diet.com.

Continue Reading Coconut Spinach

Coconut Spinach

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Ingredients:

  • 2 cups unsweetened coconut milk
  • 4 large baking potatoes
  • 1/2 cup unsweetened dried coconut
  • 1/2 cup flour
  • 1 teaspoon baking powder
  • 1/4 tsp. Salt
  • 3 free range eggs, beaten
  • Coconut oil
  • 1/2 cup butter, melted, for serving

Directions:

Boil the potatoes in their skins, cool slightly and peel. Mash the potatoes. Add the eggs.

Sift the flour together with the baking powder and salt. Beat this mixture
into the potato and egg mixture.

Add the coconut milk. Drop batter by large spoonfuls onto a hot heavy frying pan, well-greased with coconut oil. Turn the pancakes when golden on one side (3-4 minutes). Cook until the second side is golden brown.

Serve with the melted butter on the side. Serves 4 to 6.



This recipe is especially good if you are on a coconut oil diet! If you want to learn more about how to lose weight with coconut oil, check out my website at http://coconut-oil-diet.com

Continue Reading Coconut Potato Pancakes (also called Coconut Fritters)

Coconut Potato Pancakes (also called Coconut Fritters)

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We all know it’s impossible to get the kids to fall in love with vegetables, but we’ve got the recipes to help you trick them!

How many of you have struggled with getting your kids to eat vegetables? Because I have! Though I don’t have kids of my own just yet when my niece sees anything on her plate she’ll have a temper tantrum. It has become impossible to make her fall in love with vegetables. Today, on Eat Your Vegetable Day, I’ve looked on recipes to trick our kids into thinking they’re not eating veggies. How smart is that!?

Hidden Veggie Burgers

This recipe from Tasty is one that will have the kids asking for a second burger.

Ingredients needed:

2 lb of ground beef

1 tablespoon of salt

1 teaspoon of black pepper

1 teaspoon of garlic powder

1 teaspoon of onion powder

2 carrots (shredded)

2 head of broccoli (shredded)

12 cheese slices

12 burger buns

Kelapo Coconut Oil Non-Stick Cooking Spray

In a large bowl, add the ground beef, salt, pepper, garlic powder, and onion powder. Using your hands mix the seasoning with the ground beef and make sure that it’s evenly distributed. Using a shredder, shred the carrots and the broccoli heads and add to the ground beef. Use your hands to mix the veggies with the ground beef. Once mixed together, make 12 small patties by shaping them in your hands. Spray the Kelapo Coconut Oil Spray on the skillet and make about 3 to 4 patties at a time. Top with cheese on the skillet before serving the patty so the cheese melts. Serve on buns with ketchup and mustard. Your kids won’t be able to tell the difference!

Broccoli Pesto Pasta

This pasta may have a green sauce, but your kids will see noodles and definitely not give it a second guess when eating them.

Ingredients needed:

1 cup of broccoli florets (steamed)

1 large handful of fresh basil

1 garlic clove

½ cup of grated parmesan

Salt (to taste)

½ cup of olive oil (more if needed)

Boil up your kid’s favorite pasta then drain and set aside. In a food processor add the broccoli, basil, garlic, parmesan, and salt. Pulse all the ingredients together until they are finely chopped. In between pulses, pour in the olive oil a little bit at a time. Scrape the sides, and check if the consistency is that of pesto sauce. If not, add a bit more olive oil and pulse again.

Peace, love and Kelapo

-Gabriella

Continue Reading Eat Your Vegetables

Eat Your Vegetables